News for hackers. Stuff that matters.
Re:Pfizer's oral Covid-19 antiviral cuts hospitalization, de... by refurb on Friday November 05, 2021 @11:41AM (#29120870)
As someone who worked in toxicology, this is absolutely a false statement. This molecule is a covalent binder - it basically attaches itself permanently to proteins. It absolutely could have effects long after the free molecule is metabolized and excreted. The molecule is designed to be selective for the Covid protease but off-target effects are inevitable.

Do I think that is likely? No, because the FDA isn’t stupid and screens for obvious toxicity in cell cultures and lab animals and only then is testing humans allowed. Then those are screened before approval.

Of course the risk isn’t 0%, but it’s pretty low and if you’re at chance of dying or Covid it’s a pretty small risk relatively speaking.

Re:Pfizer's oral Covid-19 antiviral cuts hospitalization, de... by yosito on Friday November 05, 2021 @01:44PM (#29122468)
> this is absolutely a false statement. This molecule is a covalent binder

That's why I said if, I know nothing about the molecule.

Re:Pfizer's oral Covid-19 antiviral cuts hospitalization, de... by donkarma on Friday November 05, 2021 @03:07PM (#29123508)
But you're giving statements out like you know everything about it, and the fact you said if has no relation with the fact it binds to proteins