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A comment on Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%. Parent comment

Re:Pfizer's oral Covid-19 antiviral cuts hospitalization, de... by sudosysgen on Friday November 05, 2021 @11:23AM (#29120576)
It's not a non-statement, such effects are a serious concern for nucleoside analogs. But I can't say it's an actual issue or that it's definitely not because we just don't have sufficient data.

You're correct that almost anything with a pharmacological effect has such concerns, which diminish with time. That's why prevention is superior to treatment.

Also I wasn't talking about Paxlovid, but molnupiravir, which you'd also be taking.

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Re:Pfizer's oral Covid-19 antiviral cuts hospitalization, de... by datameta on Friday November 05, 2021 @11:37AM (#29120799)
I don't know enough about the difference between how viral RNA polymerase and human RNA polymerase function, but my hunch is the nucleotide substitution might not apply to us. This could be wrong.
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Re:Pfizer's oral Covid-19 antiviral cuts hospitalization, de... by sudosysgen on Friday November 05, 2021 @12:56PM (#29121886)
That's the hunch these drugs are based upon. But things in biochemistry are rarely black and white. There are people with serious experience in the field saying that there is a risk.

Certainly the risk is lower than untreated covid, but it's just that if you can avoid the risk then all the better.

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