Not really, and you shouldn't try. The highest recorded price for 1 USDT was $1000 at a centralized exchange, and do you really trust your counter-party in a DeFi transaction not to get flash-loaned into oblivion or to rely on a bad oracle? [1] You also have to post crypto collateral which may get rekt alongside a Tether collapse. Who even knows what that might look like? The only way to win is not to play.

[1] http://rekt.news

The only realistic way to short tether is to take a DeFi Tether loan and use some other stablecoin (You must trust that it's peg will hold longer than USDT's) as collateral.