Yes the most notable effect is I can eliminate the commuting time and spend that to exercise outside (for 2 hours!). Now I can come back to improve my running distance, discover the joy of bicycling and so much more! But I miss the interaction with real people. Sure you have application to help with chatting and meeting but somehow I long for the real connection. And I'm speaking from the perspective of an introvert. There's something that remote working can replace the serendipity. I felt I had much more creative ideas when working onsite.