The analogy I like here is those "collect the letters" games you see at fast food outlets and grocery stores. Buy a Happy Meal, get a scratch off ticket. If you collect all the letters in some phrase you win $N million. When you start the game, the trend is great. Letters are arriving and the phrase is filling in. But try as you might, that last letter never shows up. The game ends and you've won nothing. Of course, the way the game was designed was that last letter controls how many winners there could be. All the rest were distractions.
I find it weird to use a deliberately rigged game as an example. If one of the previous letters was wrong, the last letter being right means you don't win either. It's like saying the difficult steps are going to be extra difficult because other steps were found easier than expected.
You could argue that the priors were garbage I suppose. I'm not arguing for any particular probability.
The McDonalds example does not have independent variables as X1..Xn-1 are deliberately increased as Xn is decreased. I'd also argue that origin of life doesn't have independent variables. If chemistry turns out to be more or less powerful in one setting, it should do something for our assessment of other settings, especially when it's similar processes.