They cause price distortions for consumers by creating state-sanctioned monopolies. Monopolies are a type of market failure and do a great deal of harm. The commonly cited goal of giving monopolies to little inventors and helping the underdog is not a good justification; it doesn't create any value for the user/consumer and ensures they will have fewer choices in the marketplace.
Don't fool yourself, it's not patent trolls that are the problem, it's the whole system. The only innovation I want to see in patents is a huge worldwide lobbying operation to abolish them and make sure everyone knows how detrimental they are to consumer choice.
The more common argument I hear is: Why would a company invest resources into research if there was no way to prevent a competitor from copying the result on day 1 of you selling a product?
Conversely, the success of the web is entirely dependent on not hitting patent walls. We've all seen the problems of app stores with arbitrary rules and 30% taxes; if there had been a patent on, say "using images in a web browser", how much money would the holder have extracted and how many arbitrary rules would we have had to deal with?
(This nearly happened with GIF)
If your business cannot survive without a state enforced monopoly, it's a business that can't support itself and should not exist.
People often point to drug development to illustrate your point about the necessity of patents, but how about a world in which drug development is public and funded by government as well as industry participants and a "drug company" becomes more of a "drug manufacturer" making generics. Lower profits, but consumers benefit from more selection, and I would argue the science of drug discovery would move faster because it could focus on discovery more than legal bullshit. If your interest in medicine is literally only money, maybe you should try something else other than medicine. Medical innovation did not start with patents.
As a point of shameless self-promotion, I'm the founder of a company seeking to improve the patent system, starting with prior art search [1][2]. We're not one of those companies that will do it for you for less. Instead, we empower you to do it yourself, then have your attorney go deeper if needed. The idea being that you don't need to be a patent expert or lawyer to do it; anyone with knowledge of their technical area can search effectively. Plus we've got some collaboration features so when you're ready to hand off to your $500/hr attorney, you can. And not just hand off -- collaborate.
If a patent troll is shaking you down, reach out to us and we'll do you a generous deal, no strings attached. We very much do not like patent trolls.
[1] https://www.amplified.ai/
[2] https://www.amplified.ai/en/blog/22062020/introducing-amplif...