I mean, yeah. You're not going to be running anything 32-bit, and you can't use OpenGL or Vulkan, which already rules out a decent handful of workflows (including but not limited to my own). On top of that, there's legendary Docker issues that plague pretty much anything running MacOS, and there still isn't a competitive, complete package manager. eGPUs are almost completely off the table, and if they do work you won't be allowed to run an Nvidia card, you can't use CUDA, and OpenCL is fully depreciated.

So yeah, there's still quite a few holdouts on the MacOS and ARM side of things. Unless you're confident that your workflow functions perfectly on ARM, you should probably stick with a nice x86 machine for the foreseeable future. Apple will definitely improve on this model, so if you are dead-set on buying one I probably wouldn't spring for the first-gen anyways. Just my two cents though.