Re:Elizabeth Holmes is on trial for fraud, but don't forget ...
by colechristensen on Friday October 22, 2021 @09:55AM
(#28957208)
To be fair, engineering bacteria to produce a single enzyme as an MVP is an afternoon activity for a single person. You can watch it done on youtube. (you do have to wait some weeks to get your gene sequences or plasmids or whatever manufactured then you have to culture etc. and it doesn’t always work…) But in general it’s not out of the ordinary to think you could do the engineering part in a day.
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Re:Elizabeth Holmes is on trial for fraud, but don't forget ...
by dnautics on Friday October 22, 2021 @10:53AM
(#28958007)
Even a trivial due dill on cerezyme which is the gaucher's disease enzyme that blue turtle was proposing would have revealed that approved formulation is encapsulated in a membrane, has a membrane anchor (which bacteria cannot natively produce), has glycosylated protein (which bacteria cannot natively produce), not to mention "how the hell do you deliver a protein through the intestinal barrier" and "how do you target probiotic to the intestine", "how do you keep intestinal probiotics there", "what is the plan to measure uptake variations in the population" etc. etc.
Like seriously, i was able to look this up on wikipedia in the timespan of their demo pitch.