If the job is really lousy, then the sense of relief is tremendous. I recall working with a paranoid psychopath founder for a year and a half, having had enough when they fired our top manager/architect because he dared doubt her sanity, handing a letter of resignation to my long-suffering co-manager (who was in no way responsible for the situation) and walking out the door into the bright sunshine on a perfect summer day.

Fired up my festiva, turned the radio on loud - it was playing Taking Care of Business! Really! Putting it in 2nd gear and cruising through town slowly with the windows down and so happy.

Spent months unemployed, ended up starting a consulting partnership. One of the best career moves I ever made. Never depressed for a millisecond.