News for hackers. Stuff that matters.

A comment on Exome sequencing and analysis of 450k UK Biobank participants.

Re:Exome sequencing and analysis of 450k UK Biobank particip... by jasonhansel on Wednesday October 20, 2021 @08:45PM (#28938843)
A reminder that these sorts of genome-wide studies are not particularly reliable due to the problem of multiple comparisons: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270946/
[ Parent | on HN ]
Re:Exome sequencing and analysis of 450k UK Biobank particip... by gwern on Wednesday October 20, 2021 @08:51PM (#28938882)
A reminder that these sorts of genome-wide studies haven't used 0.05 but genome-wide significance (10e-8 usually, and 10e-11 in OP) for a decade now for precisely that reason, and have since replicated just fine, thank you very much.
[ Parent | on HN ]
Re:Exome sequencing and analysis of 450k UK Biobank particip... by aabaker99 on Wednesday October 20, 2021 @09:16PM (#28939079)
https://en.m.wikipedia.org/wiki/Bonferroni_correction
[ Parent | on HN ]