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Re:Evidence for European presence in the Americas in AD 1021 by not2b on Wednesday October 20, 2021 @03:42PM (#28935240)
It's possible that syphilis was brought back to Europe from the New World by the Spanish. That hasn't been proven though.

From https://en.wikipedia.org/wiki/History_of_syphilis :

The first recorded outbreak of syphilis in Europe occurred in 1494/1495 in Naples, Italy, during a French invasion ...

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