On most of my machines I switch to the integer scale mode, but realistically, the effect on sharpness is not too far from antialiasing in practice. I am not sure how they do compositing of media on macOS though. Theoretically they can render them on a distinct layer that corresponds to the output display pixels and directly composite that layer to avoid an additional resampling.

Windows on the other hand, does the theoretically correct thing but messes up the ecosystem (unsupported apps, multiple monitors)