I suppose that depends on if we are in a "hands off" simulation or one that is being actively modified. It would also depend on the purpose of the simulation, the duration, the ethical views of the being(s) running the simulation. It seems to me that there is a lot more that can go wrong, so to speak, with a simulation than there is with base level reality. There are more things that can go right as well though, technically a simulation could implement an after life or reincarnation or have some means of exiting the simulation.