I mean if you want to run existing configurations on your setup. Those aren't going to work. You can just install Nix on void though.

I had some users too but it still wasn't really worth it. I can't suggest it as a business model or a hobby project, you are basically going to be highly constrained by everything else on the system and your setup will just start looking like everything else eventually. Systemd also works fine as a session manager for whatever.