Look at the comment down-thread. Only 44% of a set of highly cited clinical trials had been successfully replicated and 32% appeared to be wrong when replications were done. That's for clinical trials, let alone stuff like social psych! Given a random clinical trial it is in fact pretty reasonable to assume it's wrong, and might even be rational, given that you'd hope highly cited and impactful studies are more likely to be correct than not.

But don't take my word for it. Take it from a former editor of the BMJ:

https://blogs.bmj.com/bmj/2021/07/05/time-to-assume-that-hea...

"Science" really is just that terrible, unfortunately.