Re:Canada's 'gamble' on delaying, mixing and matching Covid-...
by bakuninsbart on Sunday October 10, 2021 @08:37AM
(#28817940)
I got cross-vaccinated here in Germany due to being young and getting Astra Zenica as a first dosis. I still had the choice between a second dose of Biontech and AZ, so I read quite a bit about it at the time, and for example one of the leading Virologists in Germany basically said he wouldn't know why it shouldn't work. Basically, the data suggests that there isn't a suprising mechanism that does lead to less protection.
For most vaccines, the time between doses is measured in months, not weeks. Those vaccines were tested slowly over years, and the tests focused on finding the most effective timing between doses. Covid-19 vaccines were developed in a hurry, and the priority was getting them approved as quickly as reasonably possible. Testing therefore focused on the shortest time between doses that was expected to produce good enough results. Even if longer spacing was expected to be more effective, testing it would have delayed the approval by months.
Mixing vaccines also makes theoretical sense. Exposing the immune system to a more diverse range of threats may provide a more robust response when the virus mutates. Testing mixed vaccines is just more difficult in practice, because each company develops and tests its vaccines independently.