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A comment on Intestinal drug shown to boost memory and cognition. Parent comment

Re:Intestinal drug shown to boost memory and cognition by brigandish on Monday October 04, 2021 @07:39AM (#28745426)
> Prucalopride is a 5-HT4 agonist which is taken primarily for constipation. It doesn’t have significant side effects if taken under medical supervision, although doctors caution of the possibility of headache, gastro-intestinal symptoms such as abdominal pain, nausea and diarrhoea, and fatigue or dizziness; there were no significant side-effects shown by any of the volunteers taking prucalopride in this study.

Seems like it only does its usual work if you're actually constipated, otherwise it does nothing (aside from this possible memory stuff).

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Re:Intestinal drug shown to boost memory and cognition by bell-cot on Monday October 04, 2021 @11:52AM (#28748329)
Further up, the wording is:

> Prucalopride is primarily prescribed for constipation, and has an acceptable level of side effects if taken under medical supervision. (Italics mine.)

That seems rather different, and far less reassuring.

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Re:Intestinal drug shown to boost memory and cognition by brigandish on Monday October 04, 2021 @07:48PM (#28753860)
Although:

> there were no significant side-effects shown by any of the volunteers taking prucalopride in this study.

So, you can experience them and if you do they're acceptable (medically speaking, I'm not sure how acceptable I'd find them experentially). The supervision level is light touch, the volunteers weren't rigged up to a drip in an ICU.

I'm not advocating this drug, you may as well purchase some 5HTP from your choice of shop, but it doesn't seem dangerous at all. Exercise and diets have similar warnings and possibly worse side effects.

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