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A comment on High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape. Parent comment

Re:High genetic barrier to SARS-CoV-2 polyclonal neutralizin... by jopsen on Monday September 20, 2021 @06:25PM (#28599836)
> the immune system is exposed to many spikes that way...

Why not just develop anther vaccine or two? Wasn't the point with the mRNA vaccines that they would easily be tweaked to target another spike?

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Re:High genetic barrier to SARS-CoV-2 polyclonal neutralizin... by angelzen on Monday September 20, 2021 @06:58PM (#28600105)
While I am a complete neophyte, from what I learned so far immunity is non-linear. Antibody dependent enhancement and original antigenic sin come to mind. We can't just pile up vaccines and expect the effects to always be positive.

https://en.wikipedia.org/wiki/Antibody-dependent_enhancement

https://en.wikipedia.org/wiki/Original_antigenic_sin

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Re:High genetic barrier to SARS-CoV-2 polyclonal neutralizin... by jopsen on Tuesday September 21, 2021 @07:08PM (#28611158)
Wow, the immune system is complex.
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