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A comment on High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape. Parent comment

Re:High genetic barrier to SARS-CoV-2 polyclonal neutralizin... by dougmwne on Monday September 20, 2021 @06:20PM (#28599785)
No, their engineered mutant completely evaded normal immunity, but that was the purpose of the study, to find a virus that would, then test it against the super immunity discovered in some individuals. This super immunity was able to neutralize the virus, helping to support the idea that there is a special immunity in certain infected then vaccinated people that we should strive to replicate in future vaccines.
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Re:High genetic barrier to SARS-CoV-2 polyclonal neutralizin... by beerandt on Tuesday September 21, 2021 @11:26AM (#28605981)
But this was only based on the spike protein.

Natural immunity targets far more locations than just the spike. Whereas the Pfizer vaccine only targets that spike.

So it presents a scenario with crippled natural immunity vs the full capabilities of the mRNA vaccine.

Which means in this "super mutant" scenario, the mRNA will always need natural immunity be effective, but natural immunity will only need vaccination if both the spike is mutated as described, and if non-spike targets are also mutated to be resistant.

Which is far more unlikely than the already unlikely "super mutant" spike.

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