Ailes is an advocate for his political views, and business is just the latest way he advances them. Even if he's somehow uninvolved in content direction, Fox News doesn't get a free pass with "it's just business." A lot of destructive things have been done in the name of profit, and poisoning the national discourse is no different.
Ailes is a means to an end. If right wing news is the business opportunity you want to pursue, you hire Ailes. I'm speaking from the perspective of Murdoch here.
I never intend to justify Fox News, only explain it.
What people don't realize is that Fox News serves a commercial rather than an ideological agenda. The rest of the news media (especially when Fox News started) has a slightly liberal bias, which means the big business opportunity for Fox was right-wing news. It's not that they have a political agenda, they're just giving people what they want--news coverage that aligns to their political bias. As the TV viewing population has skewed older, Fox News has pushed even further to the right to match their target market. Likewise, the business opportunity for the Fox network was young adults. (And for The Sun in 1970, the target market was presumably working class British males who wanted to see topless girls in their tabloids.)