Re:Where is the scrutiny over FDA’s role in the overdose epi...
by reedjosh on Thursday September 16, 2021 @02:36AM
(#28548766)
>TSW seems like it's not very well supported by data?
How would you design an ethical experiment to get said data?
Particularly considering the timespans involved.
Please review the following case study(s).
https://www.medicaljournals.se/acta/download/10.2340/0001555...
In some of the children it took over two years, but every child was left with normal skin or mildly itchy skin in their inner elbows or behind their knees.
Nothing like the dehibilitating steroid withdrawal these children and my son went through.
Re:Where is the scrutiny over FDA’s role in the overdose epi...
by refurb on Thursday September 16, 2021 @04:07AM
(#28549260)
Your reference are case reports and even has this disclaimer "While TSW was considered the most likely diagnosis in these children, confirmation was not possible partly due to the fact diagnostic criteria for TSW did not exist when they were first assessed, and partly due to the inability to completely exclude all differential diagnoses".
And of course you can ethically confirm this data through a clinical trial. Enroll kids with specific diagnoses, treat half of them with steroids, half without and compare outcomes.
I'm not saying TSW doesn't exist, but the evidence for it doesn't look very conclusive.
That said, topical steroids beyond 1% hydrocortisone are powerful drugs that can have long-term side effects (thinning of skin). But on the flip-side, there are often no alternatives.