Re:Considerations in boosting Covid-19 vaccine immune responses
by nradov on Wednesday September 15, 2021 @06:11PM
(#28545056)
We can generalize that a bit and say that most medical research on all topics contains some dodgy data.
https://journals.plos.org/plosmedicine/article?id=10.1371/jo...
The quality of COVID-19 research has been pretty bad across the board with researchers racing to publish and journals doing weak reviews. But I haven't seen any credible allegations of fraud against the specific studies that I linked above.
There are multiple other hypothesized mechanisms of action beyond antagonizing IL-6. It's not completely clear what, if anything, is actually happening in vivo.
https://journals.lww.com/americantherapeutics/fulltext/2021/...
https://www.buzzfeednews.com/article/stephaniemlee/ivermecti...
https://gidmk.medium.com/is-ivermectin-for-covid-19-based-on...
Not to even mention that the only realistic effect it would have is blunting the effects of IL-6. There’s better options for antagonizing IL-6 with less of a side effect profile, specifically tocilizumab and sarilumab.
If you refer to blocking nuclear import, ORF6 in SARS-CoV and other sarbecoviruses already does that to begin with. Adding SARS-CoV ORF6 to a MHV model actually made it more pathogenic, so there is little benefit to not blocking nuclear import.
Here are some associated material on the topic:
https://journals.asm.org/doi/10.1128/JVI.01012-07
https://journals.asm.org/doi/10.1128/jvi.01308-07
https://journals.asm.org/doi/full/10.1128/JVI.79.17.11335-11...
https://www.sciencedirect.com/science/article/pii/S221112472...