Re:Israel’s Covid-19 boosters are preventing infections, new...
by criticaltinker on Thursday September 02, 2021 @12:47PM
(#28394325)
Fair enough, here are some high quality RCTs that provide the strong clinical evidence you're looking for.
[1] Ivermectin in combination with doxycycline for treating COVID-19 symptoms: a randomized trial https://pubmed.ncbi.nlm.nih.gov/33983065/
[2] Fluvoxamine: A Review of Its Mechanism of Action and Its Role in COVID-19 https://www.frontiersin.org/articles/10.3389/fphar.2021.6526...
[3] Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 https://pubmed.ncbi.nlm.nih.gov/33306283/
[4] Remdesivir for the Treatment of Covid-19 - Final Report https://pubmed.ncbi.nlm.nih.gov/32445440/
None of these papers seem to present strong clinical evidence that these drugs have actually been effective, vs some hidden covariate or something. A couple include interesting small-sample observational studies, but as I understand it those haven’t panned out in follow-on randomized controlled trials that have been done.
There are also a couple essentially viewpoint articles that are interesting. [2] is basically a pharmacokinetic calculation motivating further study, but no clinical data.
[4] is a hypothesis piece about hydroxychloroquine that draws on nine other studies. Haven’t been able to evaluate those because [4] is not open access, but this is one of the drugs that has not lived up to expectations in various RCTs that have been completed…