The threshold for starting new research projects from scrath is getting much higher all the time. When Smalltalk was developed you could implement most of the software stack in a quite small team in a few years. I’m not sure that is possible anymore if you want to connect to outer world eg. web. You will create dependencies out of your control quite fast. These dependencies will shape design decisions. Lowest common denominator rules and fighting that will take considerable resources and effort. I think this is one reason we are stuck with Unix like file based systems for most foreseeable future