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Re:Immunity Generated from Covid-19 Vaccines Differs from an... by rcxdude on Thursday August 26, 2021 @03:00PM (#28319072)
I think it's because the other parts of the virus are more likely to change over time, because there's lots of neutral mutations available: changes which don't affect fitness but do affect antibody response. The RBD by contrast is much more constrained: most mutations there result in a virus which can no longer infect cells, so it's much less likely to change (though of course any mutations which increase its effectiveness will be heavily selected for). This I think was one of the main reasons the spike protein was targeted by the mRNA viruses.

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