Re:Comparing SARS-CoV-2 natural immunity to vaccine-induced ...
by trhway on Wednesday August 25, 2021 @10:15PM
(#28309789)
the way you describe it sounds like the natural way is more resistant to mutations. And the low efficacy of the current vaccines against delta dovetails well to it.
>they'll tend to be specifically tailored to recognizing the surface spike
the situation is worse than that. Most of the current covid vaccines are targeting only a segment of the spike protein, and all those segments are largely overlap, ie. union of those segments of different vaccines isn't much bigger than their intersection, so just a couple of mutations (https://journals.plos.org/plosone/article?id=10.1371/journal...) is enough for the virus to escape almost all of those vaccines.
>they'll tend to be specifically tailored to recognizing the surface spike
the situation is worse than that. Most of the current covid vaccines are targeting only a segment of the spike protein, and all those segments are largely overlap, ie. union of those segments of different vaccines isn't much bigger than their intersection, so just a couple of mutations (https://journals.plos.org/plosone/article?id=10.1371/journal...) is enough for the virus to escape almost all of those vaccines.