Consider hacker mentality. You have a complex system that's not functioning the way it should. Do you drill to the root problem or just patch it temporarily? Weight gain is a problem, and the possible environmental contaminants and other causes behind society-wide weight gain are of interest as a big problem to solve. Workaround hacks like producing more insulin don't drill into the root cause. My first impulse (and probably that of most people here) is to identify what is being sold and then read what's known about the biological pathways it leverages. Not that we wouldn't all mind being fitter. But some argument needs to be made that altering basic cellular biochemistry for up-to 15% weigh loss has a risk/reward profile better than seeking root causes and addressing those, which any coder worth their salt would try to do first.