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Re:Amazon Genomics CLI by geoffjentry on Saturday August 21, 2021 @01:28PM (#28258804)
> There’s a certain base level of complexity that can be hard to abstract away

100% and a conclusion I came to far too long into my tenure in the bioinformatics workflow domain. It is also why I soured a bit on some of the GA4GH efforts in the same space (WES & TES in particular).

I still very much agree w/ the goals & ideals (respectively), but in my experience the middle ground between "I don't care, just give me the defaults" and "please do not abstract away any of the complexity, I need that" is quite small. And that zone would be the sweet spot for these efforts.

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