It's possible, but I find it extremely unlikely. The "end of physics" has been predicted several times, even in the face of obvious unanswered questions, like today's "what's the deal with dark matter and dark energy?", "can chaotic processes be understood?", "what even _is_ gravity?"

When in the past, unanswered, mystery questions like these were finally answered (for example "how come light seems to appear in discrete packets?"), the answer ended up being a door to a completely new understanding of reality, and not a little footnote question at the End of Physics

So yeah, when there are no more unanswered physics questions, I will consider that the laws of physics have been exhausted. Right now that's not the case.