Completely agreed. Except for the very very few cases where Word is better (e.g. printing out lots of pictures), I make a point of using LaTeX whenever possible. It’s just so much less painful than anything else.

This you?

https://github.com/bradrn/brassica/blob/master/README.md

Yes, that’s me. Why do you ask?

Doesn't look like LaTeX

OK, perhaps I should have added a qualifier to my previous statement: when making offline documents, I use LaTeX whenever possible. Generally speaking, PDFs in a web browser aren’t particularly nice to read, so LaTeX doesn’t work so well with online documents. As for your specific example: if the entire project is already on GitHub, of course the sensible decision is to use Markdown, since that’s GitHub’s native format. (And if Markdown isn’t enough, then I’ll fall back to LaTeX: e.g. documentation for [0].) For non-web documents, however, I always use LaTeX in all but a small number of situations.

[0] https://github.com/bradrn/Conkey

You're in the minority. I haven't seen any LaTeX readmes on github.