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Re:Launch HN: Matrubials (YC S21) Milk-derived therapeutics ... by DantesKite on Friday July 30, 2021 @03:14PM (#28011292)
It would be remarkable seeing this technology applied to restoration of the gut microbiome.

It seems to be involved in so many autoimmune diseases.

Heavy antibiotic use also seems to irrevocably damage the diversity of gut bacteria, leaving individuals susceptible to a lot of health complications later down the line.

Anecdotally, I know raw kefir and Visbiome (a well-studied probiotic) has been very helpful for the restoration of the gut microbiome.

Re:Launch HN: Matrubials (YC S21) Milk-derived therapeutics ... by ishishah on Friday July 30, 2021 @03:22PM (#28011351)
Amen to that. Restoration of the gut microbiome is key to life-long health, starting with infancy, where colonization by the "right" beneficial bacteria is really important.

Infact, milk does a remarkable job with that. One example: diverse group of complex oligosaccharides present in milk and reaching the colon intact serve as food for the beneficial bacteria, allowing them to dominate the infant gut and present a wide array of benefits.

Re:Launch HN: Matrubials (YC S21) Milk-derived therapeutics ... by chrisco255 on Friday July 30, 2021 @08:50PM (#28014172)
Does pasteurization mess with this effect at all? Is raw milk better?
Re:Launch HN: Matrubials (YC S21) Milk-derived therapeutics ... by ishishah on Friday July 30, 2021 @11:08PM (#28014915)
Hi! Pasteurization is not known to impact the structure or function of human milk oligosaccharides. But there are certain heat labile molecules that are impacted by it, and raw milk may retain those.

But there is a whole another story with raw milk and pathogenesis. If interested, check this article: https://pubmed.ncbi.nlm.nih.gov/32591006/

Re:Launch HN: Matrubials (YC S21) Milk-derived therapeutics ... by matsemann on Friday July 30, 2021 @05:31PM (#28012611)
Since peptides is mentioned, BPC-157 is popular for certain gut/digestive problems.