1. I use home/end a lot, both for text editing and jumping to the start/end of lists with keyboard navigation.

2. I've tried rebinding to escape but just got frustrated by inconsistency, so now I just leave it unused.

3. Thinking about it, I have two modes, "gaming" where my right hand is in the mouse and left on wasd, where I tend to use my left thumb for spacebar, and "working" where I have both hands on the keyboard and just use whichever is most free at that point.