More Protein Folding Progress – What’s It Mean?

Re:More Protein Folding Progress – What’s It Mean? by FartyMcFarter on Monday July 26, 2021 @08:09PM (#27967090)

> AlphaFold's approach seems like a recipe for over-fitting.

Doesn't the CASP competition use unknown structures, which would have defeated over-fitting?

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Re:More Protein Folding Progress – What’s It Mean? by COGlory on Tuesday July 27, 2021 @08:10AM (#27971468)

No, because 3D folds are conserved. That means, short of one of the unknowns containing a novel fold (which they havent), theres always a possibility kf overfitting.

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Re:More Protein Folding Progress – What’s It Mean? by l33tman on Tuesday July 27, 2021 @03:50AM (#27969754)

It does. I'm not sure what the poster above is referring to.

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