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Re:More Protein Folding Progress – What’s It Mean? by dekhn on Monday July 26, 2021 @04:16PM (#27964851)
Reasonably speaking, I would expect that within 2 years 10 groups will be as proficient as AF2 at predicting static structures. I don't think anybody who is trying to emulate physics simulations will be in that group, just folks who have learned enough tricks to quickly incorporate all the evidence during training and choose how to apply it during prediction.

I expect to see a "multiple feature embedding heads on top of 2 fullly connected layers" (as used in modern ads training) will end up being the simplest architecture capable of folding proteins well.

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