It doesn't work well in print. It's less legible than more common typefaces in comparable sizes on account of its lightness, for certain printing technologies
It works well in print if tuned to the printing technology, as originally designed. You should be able to adjust it (again, as designed) for the print technology you are using.
Most common typefaces are useless for mathematics, so it's a bit of an oranges and apples comparison anyway.
It works pretty well balanced in print on systems it was originally targeted to. The main problem with using other fonts in TeX/LaTeX (or anything in, say, Word) is making it so complex equations lay out reasonably. Admittedly a niche problem, but one one that was the original purpose of TeX - and CM works well for it. There are a small number of other options that don't screw it up.