For those that are unaware, industrial protein design is a multibillion dollar industry. For example, decades ago Genentech and Dow Corning formed a company that developed proteases (proteins that cut other proteins) that worked at much higher temperatures than the ones in nature. This was then sold to P&G and other major laundry companies (laundry detergent contains idle enzymes activated by the heat of the laundry water, and they go clean up. "Protein gets out protein" was the marketing jingle.

That was a few billion dollars right there and almost all the work was done by hand by lab scientists.