Here is one short analysis from the country simulated in the game, that is Czechia.

One of the regions got an alpha variant wave sooner and the local hospitals actually went over capacity, with triage going on. You can see it in the time-variable CFR plots.

https://www.linkedin.com/pulse/what-cfr-data-can-tell-us-pan...

Roughly it seems case fatality rate increased almost 2-fold, despite hundreds of patients being transported out of the region by ambulances.

( https://translate.google.com/translate?sl=auto&tl=en&u=https...)