I have stopped watching German dubs long ago, but I watched a lot of the German dub of Scrubs during its original run, and much later came across the original English version. It's incredibly striking how the dubbing changed the character of Dr Cox: In the German dub, he's portrayed in a high-pitched voice, rendering him a maniacal goofball, whereas McGinley's original performance uses a deeper flatter voice that made him appear much more psychopathic (though admittedly I only saw one episode in English, so that may be cherry-picking).