If you’re applying for mid level up and the only relevant experience you have for the role is a github profile with side projects, thats not going be enough to get an interview. Recruiters who screen candidates won’t even check out github profiles let alone evaluate their content.

Degrees are not really a hard barrier nowadays to get interviews. What’s important is relevant experience. OP doesn’t sound like they have relevant professional experience to the roles they’re applying for. which is probably why they are not getting interviews and is incorrectly blaming their lack of degree as the reason