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A comment on What mRNA is good for, and what it maybe isn’t. Parent comment

Re:What mRNA is good for, and what it maybe isn’t by jostmey on Tuesday June 29, 2021 @10:11PM (#27684138)
Everyone seems to be focusing on your first comment at the dose must to be limited to 30 µg to avoid lipid toxicities. But the second issue is an even bigger issue—-the immune system will remove cells expressing proteins not found in the patient’s genome.
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Re:What mRNA is good for, and what it maybe isn’t by catlifeonmars on Wednesday June 30, 2021 @09:44AM (#27688415)
Under what circumstances does this occur? Is this something the cell itself signals to the immune system?
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Re:What mRNA is good for, and what it maybe isn’t by dekhn on Wednesday June 30, 2021 @10:16AM (#27688820)
it's one of the most extraordinary details I've learned in biology. The thymus expresses cell types from around the body and trains the immune system to not recognize them as foreign:

https://en.wikipedia.org/wiki/Central_tolerance

it's not for genes, but for epitopes

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