Metformin trial reduces seizures and brain tumours in Tuberous Sclerosis

Re:Metformin trial reduces seizures and brain tumours in Tub... by amanaplanacanal on Sunday June 27, 2021 @11:47PM (#27657927)

All this sort of study can do is to point to where there might be connections to follow up on by doing the real research: randomly assign people to diets and watch the results. But that step never seems to get done. Instead we have this endless series of “studies” which show us absolutely nothing.

You said that all cause mortality increases on a ketogenic diet, and this study shows no such thing.

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Re:Metformin trial reduces seizures and brain tumours in Tub... by esyir on Monday June 28, 2021 @02:21AM (#27658681)

You know why these don't get done?

Because that means that you're grabbing a large cohort of people, fixing their diets, and following them until a good number of them die.

The timescales required here, not to mention the cost, means that such studies are virtually unfeasible.

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Re:Metformin trial reduces seizures and brain tumours in Tub... by deeviant on Monday June 28, 2021 @12:32AM (#27658155)

> You said that all cause mortality increases on a ketogenic diet, and this study shows no such thing.

...

> The risks of all-cause and cause-specific death over an average 6.4-year follow-up rose with each fall in carbohydrate intake (see table), and remained significant after adjusting for all available factors that might have influenced the association (Model 2 in the table).

Quoted from the study.

It suggests exactly that thing. I suggest you read the study again.

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