Sure, but that's a completely different setting than the one the OP described: mass testing for presence of cancers by non-specialist labs. And that's the thing that triggered my response. The outcome of such an approach could easily be a negative one.

FWIW I too have some experience with medical diagnostic systems (specifically: cancer testing), and one of the main reasons why I'm still skeptical about this test is that for many cancer types tested for the base rate is much lower than the false positive rate.