Non-labor initial outlay for some hackers to build a software system is well under 100K.
To put together a chemistry lab takes well over 100K (or so I have been informed). Imagine having to spend 100K just to have a spot where people can work.
Those costs of course start to spiral heavily upwards as you get more and more high-tech in your hardware. Then, if you're setting up startups for the hardware world, what's the ExpectedValue of your ROI. Batting average ain't going to be great. So the incentives are skew compared to the software world.
That said, I'd love to be involved in the software side of nuclear energy. Among other things, you can't rely on your memory as a given, since it is more prone to corruption.
It all depends on what you are making. So far, the startup world seems to be in a goldrush with devestating results (both for investors, as well as participants). The article is right: why are these developers not making better simulation software? Why are they not creating the next iteration of mission critical control systems? Two words: gold rush.
So, if you talk about 'a software system', you should specify the bounds. Failing to do this, I have no choice but to diagnose you with yet another case of Silicon Valley gold fever.
Oh, it gets even more exciting than that. You can't always even rely on your computations, let alone your memory!
http://en.wikipedia.org/wiki/Radiation_hardening#Radiation-h...
For instance, I know some folks who'd like to build a new kind of nuclear reactor that uses molten Thorium salt as a fuel. The kind of system could produce all the energy you use in your life with a ball of Thorium that you could hold between two fingers.
It would probably cost these guys $500M just to fill out the paperwork to build a test reactor... Even Silicon Valley investors don't want to spend that much cash. if you think the RIAA is bad just try the NRC.