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A comment on CureVac fails in pivotal Covid-19 vaccine trial with 47% efficacy. Parent comment

Re:CureVac fails in pivotal Covid-19 vaccine trial with 47% ... by Vecr on Thursday June 17, 2021 @02:53AM (#27536840)
The other two have lots of fancy things done to the mRNA itself, including pseudouridine substitutions, 3 and 5 prime untranslated regions, and a poly-a tail. The payload comes from the NIH, and is modified by them as well with proline insertions to stabilize the spike in the prefusion form. All current EUA vaccines in the US (BioNTech, Moderna, Jansen), plus NovaVax (code not delivered to the user in that case) use some form of the NIH payload, as far as I can tell.

Edit: I forgot about the proprietary mRNA delivery systems as well, I don't really know much about those.

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Re:CureVac fails in pivotal Covid-19 vaccine trial with 47% ... by rich_sasha on Thursday June 17, 2021 @04:49AM (#27537468)
Interesting list, thanks! Do you know of any popular science description of these? I did biology at middle school and not since (but I continue to find the mechanics of low-level biology fascinating).
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Re:CureVac fails in pivotal Covid-19 vaccine trial with 47% ... by spuz on Thursday June 17, 2021 @07:13AM (#27538360)
Thanks, these are really good reads.
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Re:CureVac fails in pivotal Covid-19 vaccine trial with 47% ... by vacooom on Thursday June 17, 2021 @04:56AM (#27537504)
I found this being a very good explanation for the technically inclined: https://berthub.eu/articles/posts/reverse-engineering-source...
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Re:CureVac fails in pivotal Covid-19 vaccine trial with 47% ... by raphlinus on Thursday June 17, 2021 @02:57PM (#27543177)
Another good and accessible discussion of what went wrong with this vax is Derek Lowe's "In the Pipeline" blog:

https://blogs.sciencemag.org/pipeline/archives/2021/06/17/cu...

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