Looks nice, but it seems to have a significant price premium over GoDaddy (seems to be $14/domain/year + $120/year for DNS). Is the benefit worth the premium?

I'm not sure how many domains you handle, but in my case I have less than 10 domains so I pay $36 yearly + 8 per domain transfer from GoDaddy (or $14 as you mentioned). With one click you get stuff like Google Apps or Heroku setup for you.

After dealing with registrars for a long time I've realized that paying extra $5 per domain per year is totally worth it if you don't have to deal with companies like GoDaddy.

I'm not familiar with the Amazon service, but if it's $1 per domain per month then you'd save $0.7 for every domain using DNSimple.

EDIT: I should link to another HN discussion on the subject: http://news.ycombinator.com/item?id=2753471. One comment that resonates by jbyers: "Read your registrar's terms. See if you still want to save that $6 a year".

So you have to pay DNSimple for the service plus whatever each domain costs per year? I'm not understanding their pricing scheme very well, it seems.

There are two separate costs: one is the domain registration and the other one is the hosted DNS solution.

With the hosted DNS solution you get access to stuff like the one click setups I mentioned earlier, API access, domain forwarding, vanity name servers and who knows what else. Keep in mind you can use their DNS service even if you don't register your domains with them.

Ah, right. I use Linode's panel, but I could use some one-click Google Apps DNS records, thanks.

Actually, I've been using Cloudflare for the last couple of weeks and have been pretty happy with it so far.

Side benefits, CDN caching and threat detection/protection.

You can use something like Amazon Route53 for your name servers at much lower than that. It's $1/mo per domain + a small cost per unit of traffic