Speaking of which, guess what showed up in Wales recently? https://www.bbc.co.uk/news/uk-wales-57431322
(This kind of thing is why the UK has national-level contract tracing capabilities. Occasionally something shows up that's not particularly easy to spread, but bad enough that it needs stopping sooner rather than later. I think we've had a few SARS and MERS cases too.)
Some poxes are awful for the primary host. Camelpox apparently kills about a quarter of camels that contract it. Just like smallpox (humanpox?) kills about 25% of humans, actually. But camelpox rarely even infects humans, and is self-limiting when it does.
Monkeypox is bad in humans. Almost as bad as smallpox, but not as contagious.