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Re:HIV mRNA Vaccines-Progress and Future Paths by bawolff on Tuesday May 25, 2021 @04:01AM (#27274155)
I imagine that with normal virus evolution, many people already have at least partial immunity to the new strain as its a minor change, where if it crosses the species barrier that's a bigger "jump" so probably nobody has partial immunity so its more unchecked.

(Just pure speculation. Not my field)

Re:HIV mRNA Vaccines-Progress and Future Paths by XorNot on Tuesday May 25, 2021 @06:33AM (#27275169)
COVID-19 is unique in the sense that it sits in a neat "uncanny valley" of virulence and lethality where it's able to attack our healthcare infrastructure (aided by modern travel), but is sufficiently non-lethal that it can keep spreading. The notable issue with SARS (which was incredibly lethal) was that the incubation time was too short - one or two days before you weren't going anywhere, way too high visibility.