If on the other hand the population is already angry at the regime, maybe it has the desired effect.
Idle musing without supporting evidence.
Edit: But to be clear, I think the US sanctions on Cuba are gratuitous and cruel. Cuba is not some rogue state and there are many worse dictatorships that aren't sanctioned. However, I think it reinforces the point that "sanctions can be devastatingly effective applied by a significant majority of the world" because in the Cuba case the rest of the world didn't agree.
There were considerable limits (particularly on foreign investment in Cuba) because parts of the US sanctions regime include retaliatory sanctions on entities making use of certain property in Cuba (some of these were suspended for a while, but restored under Trump in 2017.)