Sure, especially if you make a habit out of it and pair it with a stimulant, like nicotine or caffeine, which both are routinely consumed with large amounts of MAOIs (which are found in both tobacco smoke and brewed coffee).

For an especially interesting evening, search ”monoamine oxidase” in the publicized tobacco industry documents: https://www.industrydocuments.ucsf.edu/tobacco/results/#q=%2...