- Eating questionable meat for random powers
- Losing your great items permanently
- Not getting poison resistance and putting off the hive for ages
- Not being able to carry as much as a weak character
- Putting a stash on Hive:2 so monsters can't get your items
- Being a mummy summoner and having a full screen of summons (no hunger requirement)
- Hill orc priests would wander the map gaining converts
A lot of these things became part of the game muscle memory to avoid. They were hilarious and emotional as a new player. They are now obsolete. I have mixed feelings - I always felt enough mitigation existed in the game and I enjoyed learning about it
Weight management - yes, hard to have too much nostalgia for that one
My last win was an Spriggan Venom Mage that could backstab poison resistant enemies with a +11 artefact dagger.
As I mentioned in the sibling comment, there's a vocal minority in this game loudly complaining about any change. My suggestion is to decide for yourself, play an older version if you prefer, or any of the dozen forks, all available on most public servers.
Off the top of my head, they have recently:
* removed the whole hunger/food system: no need to eat, no need to butcher corpses or collect food, magic doesn't make you hungry.
* removed cursed items: an issue only in the early game, trivially managed by careful identification of unknown scrolls
* removed unremarkable species or monsters
* removed trivial spells such as Deflect Missiles or Regeneration
That doesn't sound fun to me, and don't miss it for one second.
I think I liked it but I'm not sure it helped me master the gameplay (I sometimes felt rushed even when hunger management wasn't obviously an issue).
That being said I want to play Djinn eventually so I'll upgrade when that time comes.